Research & Development

    RESEARCH ACTIVITIES UNDERTAKEN

  • Identification of epigenetic markers for early detection of attentiondeficit/hyperactivity disorder - Funding agency: Kerala State Council for Science Technology & Environment (KSCSTE)
    • Principal Investigator –Dr. Sivaprasad M S, Post Doctoral Fellow, Dept. of Neurogenetics, ICCONS
    • Co- Investigator – Dr. Anitha Ayyan Pillai, Associate Professor, Dept. of Neurogenetics, ICCONS
  • Neurocognitive Impairment in Prostate Cancer Patients on Androgen Deprivation Therapy- Funding agency: Regional Cancer Centre, Thiruvananthapuram
    • Principal Investigator – Dr. Francis V James, Prof & Head, Radiation Oncology Dept, RCC
    • Co-Principal Investigator – Dr. Sanjeev V Thomas, Director, ICCONS & Dr. Bhagya A S, Junior Resident, Radiation Oncology, RCC
    • Co- Investigator – Sreekumar S, Lecturer, ICCONS, Dr. Jagathnath Krishna K M, Assoc.Prof, RCC, Dr. Aswin Kumar, Addl. Prof, RCC, Dr.Susan Mathews, Addl. Prof, RCC, Dr. John Joseph, Assoc. Prof, RCC & Dr. Aparna M P, Asst. Prof, RCC
  • “Comparison of the effect of training in magical sciences and a variety of art forms and training using conventional therapy in addition on behavioural and other outcomes among differently abled children- Funding agency: Collaborative Project by ICCONS & Different Arts Centre(Academy of Magical Sciences)
    • Principal Investigator – Dr. Mary Iype, Professor, Pediatric Neurology, GMC, Trivandrum & Mr. Gopinath Muthucaud, Executive Director, The Academy of Magical Sciences
    • Co- Principal Investigator – Dr. Sanjeev V Thomas, Director, ICCONS, Dr. Nisha V M, Different Arts Centre
  • Identification of specific DNA methylation biomarkers in spinal muscular atrophy and its application as a therapeutic target- Funding agency: Multidisciplinary Research Unit, Govt. Medical College, Thiruvananthapuram
    • Principal Investigator – Dr. Anitha Ayyappan Pillai, Associate Professor, Dept. of Neurogenetics, ICCONS
  • Genetic characterization and clinical correlates of polymicrogyria syndromes -Funding agency: Indian Council of Medical Research (ICMR), Govt. of India
    • Principal Investigator – Dr. Anitha Ayyappan Pillai, Associate Professor, Dept. of Neurogenetics, ICCONS
  • Photoparoxysmal EEG responses in children with idiopathic generalized epilepsyGenetic characterization and clinical correlates- Funding agency: Dept. of Science and Technology Cognitive Science Research Initiative (DST-CSRI), Govt. of India
    • Principal Investigator – Dr. Sanjeev V Thomas, Director, ICCONS
    • Co- Investigator – Dr.Anitha Ayyan Pillai, Associate Professor, Dept. of Neurogenetics, ICCONS
  • “Effect of an early intervention program in the management of cognitive, behavioral and language skills of children with ASD”.-Funding agency: Department of Science & Technology, Government of India.
    • Principal Investigator – Dr. Anitha Ayyan Pillai, Associate Professor, Dept. of Neurogenetics, ICCONS
  • “Topical Oil Pooling(Karnapurana) with KshirabalaTaila and supple Mentation of Ashwagandha Churna(TOPMAC) IN controlled trial”. Funding agency: Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India
    • Principal Investigator –Dr. Krishna Kumar V., R.O. (Ay.)
    • Co- Principal Investigator – Dr. Sanjeev V Thomas, Director, ICCONS
    • Co- Investigator – Dr. Parvathy.G.Nair, R.O. (Ay.), Dr. Nish, Asst. Professor, Dept. of ASLP, ICCONS
  • Quantification of cognitive Disability in children with the new Malayalam version of ICF-CY - Funding agency: Kerala State Commissionerate for Persons with Disabilities
    • Principal Investigator – Dr. Sanjeev V Thomas, Director, ICCONS
    • Co- Investigator – Dr. Mary Iype, Professor, Pediatric Neurology, GMC, Trivandrum, Dr. Anish T S, Professor, Dept. of Community Medicine, GMC, TVM, Dr. Murugan C Nair, Asst. Professor, Dept. of Neurology, ICCONS,TVM, Dr. Vishnu Prasad S, Research Officer, ICCONS
  • The Spectrum of Impairment and Prediction of Disability in Cognitively Challenged Children in Kerala Funding source - Centre of Excellence for Disability Studies
    • Principal Investigator – Dr. Sanjeev V Thomas, Director, ICCONS
    • Co- Investigator – Dr. Mary Iype, Professor, Pediatric Neurology, GMC, Trivandrum, Dr. Anish T S, Assoc. Professor, Dept. of Social & Preventive Medicine, GMC, TVM, Dr. Hamza Mullath, Asst. Professor in Pediatrics, ICCONS
  • Extensive mutational analysis of neural and synaptic genes using next generation sequencing approaches in Indian autism families- Funding source - Kerala State Council for Science Technology & Environment (KSCSTE)
    • Principal Investigator – Dr.Thanseem Ismail, Research Fellow, ICCONS, Shoranur
    • Co- Investigator – Dr. P. A Suresh, Director, ICCONS, Dr. Anitha Ayyan Pillai, Associate Professor, Dept. of Neurogenetics, ICCONS, Ms. Nisha M L, Assistant Professor, Dept. of ASLP, ICCONS.
  • Targeted exon sequencing to identify novel, rare and/or common functional genetic variants in autism: A comprehensive twin-family study of autism in Kerala- Funding source - Kerala State Council for Science Technology & Environment (KSCSTE)
    • Principal Investigator – Dr. Anitha Ayyan Pillai, Associate Professor, Dept. of Neurogenetics, ICCONS
    • Co- Investigator – Dr. P. A Suresh, Director, ICCONS, Dr.Thanseem Ismail, Research Fellow, Ms. Nisha M L, Assistant Professor, Dept. of ASLP, ICCONS.
  • Photoparoxysmal EEG responses in children with idiopathic generalized epilepsyGenetic characterization and clinical correlates- Funded by Dept. of Science and TechnologyCognitive Science Research Initiative (DST-CSRI), Govt. of India
    • Principal Investigator – Dr. Anitha Ayyan Pillai, Associate Professor, Dept. of Neurogenetics, ICCONS
    • Co- Investigator – Dr. Mary Iype, Professor, Pediatric Neurology, GMC, Trivandrum
  • Genetic characterization and clinical correlates of polymicrogyria syndromes- Funding source - Indian Council of Medical Research (ICMR), Govt. of India
    • Principal Investigator – Dr. Anitha Ayyan Pillai, Associate Professor, Dept. of Neurogenetics, ICCONS.
    • Co- Investigator – Dr. Mary Iype, Professor, Pediatric Neurology, GMC, Trivandrum
  • The Spectrum of impairment and prediction of disability in cognitively challenged children in Kerala-
    • Principal Investigator – Dr. Sanjeev V Thomas, Director, ICCONS
    • Co- Investigator – Dr. Mary Iype, Professor, Pediatric Neurology, GMC, Trivandrum, Dr. Anish T S, Asso. Professor, Dept. of Community Medicine, GMC, Trivandrum Dr. Hamza Mullath, Assistant Professor, Dept. of Paediatrics, ICCONS, Shoranur
  • Effect of an early intervention program in management of Cognitive, Behavioural and Language skills of children with Autism Spectrum Disorders
    • Principal Investigator – Dr. Nandini Jayachandran, Lecturer in Clinical Psychology-Grade 1 ICCONS, Trivandrum
    • Co- Investigator – Dr. Mary Iype, Additional Professor, Pediatric Neurology, GMC, Trivandrum
  • DNA methylation analysis in specific language impairment- Funding source-: Science and Engineering Research Board (SERB)
    • Principal Investigator – Dr. Anitha Ayyan Pillai, Associate Professor, Dept. of Neurogenetics, ICCONS
    • Co- Investigator – Dr. P. A Suresh, Director, ICCONS, Dr.MaryIype, Asso. Professor, Pediatric Neurology, GMC, Trivandrum, Ms. Nisha M L, Assistant Professor, Dept. of ASLP, ICCONS.
  • Early identification and intervention in Developmental dyscalculia
    • Principal Investigator – Dr. Nandini Jayachandran, Lecturer in Clinical Psychology-Grade 1 ICCONS, Trivandrum
    • Co- Investigator – Dr. Immanuel Thomas, Former HOD & Professor, Department of Psychology, University of Kerala
  • Maternal Training Program For Rehabilitation And Education Of Children With Autism – National Rural Health Mission (NRHM) Project
    • Principal Investigator – Dr. P.A. Suresh, MD, DM (Neuro), Director, ICCONS
    • Co- Investigator – Dr. Meena Menon, Lectr. in Clinical Psychology – Gr.I; Dr. Athira.T.S, Asst. Professor in Paediatrics; Ms. Nandhini Jayachandran, Lectr. in Clinical Psychology – Gr.I; Ms. Geethi.S, Lectr. in Speech Language Pathology– Gr.I
  • Genetic Study And DNA Mapping
    • Dr. P.A.Suresh, MD, DM (Neuro), Dr. Moinek Banerjee and Dr. Meena Menon
  • Comprehensive Approach To Prevention, Treatment And Rehabilitation Of Non-Communicable Disorders And Disabilities
    • Dr. P.A.Suresh, MD, DM (Neuro), Dr. Meena Menon, Ms. Geethi.S and Ms. Nandhini Jayachandran
  • Multimodal Stimulation And Psychodynamic Exercises For The Rehabilitation Of Children With Cognitive Language And Motor Disabilities.
    • Principal Investigator – Dr. P.A.Suresh, MD, DM (Neuro), Director, ICCONS
    • Co- Investigator – Dr. Meena Menon, Lectr. in Clinical Psychology – Gr.I; Dr. Athira.T.S, Asst. Professor in Paediatrics
  • Hypermethylation of AMOTL1 gene in developmental language disorder
  • Comparative study of the methylation of APCDD1 gene in developmental language disorder
  • Comparative study of the methylation of VEPH1 gene in developmental language disorder
  • Comparative study of the methylation of TRABD2B gene in developmental language disorder
  • Genetic association study of MTHFR gene with autism
  • Comparative study of the methylation of CNTNAP2 gene in developmental language disorder
  • Hypomethylation of WNT2B gene in developmental language disorder
  • Comparison of the expression of Hs-miR-9b-2 between autism patients and control subjects
  • Comparison of the expression of Hs-miR-181b-1 between autism patients and control subjects
  • Genetic association study of DRD1 rs4532 with autism spectrum disorders in Kerala population
  • Hypomethylation of GNG7 gene in developmental language disorder
  • Downregulation of TUBB2B and KAT6B in polymicrogyria
  • MECP2 mutations in the Rett syndrome patients from south India
  • Association study of MTHFR rs1801133 gene polymorphism with autism spectrum disorders in Kerala population
  • Differential methylation of WNT2B gene in developmental language disorder
  • Differential methylation of LRP5 gene in developmental language disorder
  • Thyroid dysfunction in mental retardation
  • Differential methylation of NOTCH2NL gene in developmental language disorder
  • Differential methylation of AMOTL1 gene in developmental language disorder
  • Differential methylation of APCDD1 gene in developmental language disorder
  • Differential methylation of VEPH1 gene in developmental language disorder
  • Phonetic placement technique for improving speech clarity in down syndrome
  • Speech and language manifestations in closed head injury
  • Sudden hearing loss: Case comparison study
  • Cleft lip and palate: Single case study
  • Effectiveness of voice therapy in unilateral vocal fold paralysis
  • Childhood dysarthria: Single case study
  • Speech and language characteristics in PraderWilli syndrome
  • Addressing oral sensory issues in the management of children with autism spectrum disorders
  • Speech sound disorder-A single case study
  • Importance of audiological evaluation after covid -19 infection
  • Empowering Teachers For Managing Learning Disability Through Integrated Education.
  • Epidemiological Survey Of Disability Following Stroke, Traumatic Brain Injury And Dementia In Kerala.
  • Genetic Basis Of Autism In Children With Tuberous Scleroses.
  • Genetic Basis Of Childhood Autism
  • National Program For Rehabilitation Of Person’s With Disability [NPRPD]